Transfer of mitochondria and endosomes between cells by gap junction internalization

نویسندگان

چکیده

Intercellular organelle transfer has been documented in several cell types and proposed to be important for cell-cell communication cellular repair. However, the mechanisms by which occurs are uncertain. Recent studies indicate that gap junction protein, connexin 43 (Cx43), is required mitochondrial but its specific role unknown. Using three-dimensional electron microscopy immunogold labeling of Cx43, this report shows whole organelles including mitochondria endosomes incorporated into double-membrane vesicles, called connexosomes or annular junctions, form as a result internalization. These findings demonstrate novel mechanism intercellular mediated Cx43 junctions.

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ژورنال

عنوان ژورنال: Traffic

سال: 2021

ISSN: ['1398-9219', '1600-0854']

DOI: https://doi.org/10.1111/tra.12786